Download Opera at http://www.opera.com/mail/ and run the installer.
Open the program and click Tools and select Mail and Chat Accounts
Click Yes to the following prompt: You need to create an account before proceeding. Would you like to create one now? You will see the following screen:
Email and click next
Fill in the details including your full mail address and click next
Put in your email and password, select POP and click next
Fill in your incoming and outgoing server as: mail.youdomain.com do not check TLS option and configure the rest to your preference, click Finish
You will see your email show up on the left pane of the Opera Browser, you are now ready to utilize your email setup
Usually, the port used for the Outgoing Mail Server/SMTP Service is 25. However, there might be a situation where your ISP might be blocking the use of port 25 for SMTP service. Many ISPs block port 25 in order to minimize the amount of spam sent using their network. If you are facing issues sending mails using the default port 25, you can confirm with your ISP whether port 25 is indeed blocked by them.
To circumvent this, Sibername allows you to use an alternate port 26 for sending mails if port 25 is blocked: